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・Sudan K. et al.: Free Radic Biol Med. 2019 Jun; 137: 131-142 
"TLR4 activation alters labile heme levels to regulate BACH1 and heme oxygenase-1 expression in macrophages."
Transfected cell: Human monocyte-derived macrophages
Transfected molecule: siRNA (ScreenFect™A plus)

・Osaki Y. et al.: Biochem Biophys Res Commun. 2019 Apr 24 published. 
"Calnexin promotes the folding of mutant iduronate 2-sulfatase related to mucopolysaccharidosis type II."

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Aβ ELISA kit reference List

292-62301 Human β Amyloid(1-40) ELISA Kit Wako

1. Zhang, C., et al.: J. Biol. Chem., 285, 37, 28472(2010).

Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.

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2. Serrano-Pozo A., et al.: Alzheimer Dis. Assoc. Disord., 3, 220(2010).

Effects of Simvastatin on Cholesterol Metabolism and Alzheimer Disease Biomarkers https://www.ncbi.nlm.nih.gov/pubmed/20473136

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Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density. https://www.ncbi.nlm.nih.gov/pubmed/20847415

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Plasma amyloid-β as a function of age, level of intellectual disability, and presence of dementia in Down syndrome.

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CB2 Receptor Deficiency Increases Amyloid Pathology and Alters Tau Processing in a Transgenic Mouse Model of Alzheimer’s Disease

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Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium. https://www.ncbi.nlm.nih.gov/pubmed/24860840

7. Gonzales C., et al.: Pharmacol. Biochem. Behav., 126, 28(2014).

Alternative method of oral administration by peanut butter pellet formulation results in target engagement of BACE1 and attenuation of gavage-induced stress responses in mice https://www.ncbi.nlm.nih.gov/pubmed/25242810

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Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as adjunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice

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Human mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease.

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Effect of apolipoprotein E phenotype on the association of plasma amyloid β and amyloid positron emission tomography imaging in Japan. https://www.ncbi.nlm.nih.gov/pubmed/28975146

11. Bourdenx, M., et al.: Sci. Rep., 7, 45831(2017).

Lack of spontaneous age-related brain pathology in Octodon degus: a reappraisal of the model. https://www.ncbi.nlm.nih.gov/pubmed/28374864

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Decreased N-Acetyl Aspartate/Myo-Inositol Ratio in the Posterior Cingulate Cortex Shown by Magnetic Resonance Spectroscopy May Be One of the Risk Markers of Preclinical Alzheimer's Disease: A 7-Year Follow-Up Study.

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13. Brubaker, W. D., et al.: Alzheimers Dement., 12, 1397(2017).

Peripheral complement interactions with amyloid β peptide: Erythrocyte clearance mechanisms https://www.ncbi.nlm.nih.gov/pubmed/28475854

14. Kanatsu, K., et al.: J. Neurochem., 147, 1, 110(2018).

Retrograde transport of γ-secretase from endosomes to the trans-Golgi network regulates Aβ42 production.

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Mutations in the β-amyloid precursor protein in familial Alzheimer's disease increase Aβ oligomer production in cellular models

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Nicotine and methyl vinyl ketone, major components of cigarette smoke extracts, increase protective amyloid-β peptides in cells harboring amyloid-β precursor protein. https://www.ncbi.nlm.nih.gov/pubmed/29618714

17. Kara, E., et al.: J. Biol. Chem., 293, 34, 13247(2018).

A flow cytometry–based in vitro assay reveals that formation of apolipoprotein E (ApoE)–amyloid beta complexes depends on ApoE isoform and cell type https://www.ncbi.nlm.nih.gov/pubmed/29950521

18. Kusakari, S., et al.: J. Neurochem., 144, 2, 218(2018).

Calmodulin-like skin protein protects against spatial learning impairment in a mouse model of Alzheimer disease.

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19. Meyer, K., et al.: Cell Rep. 26, 5, 1112(2019).

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer’s Disease https://www.ncbi.nlm.nih.gov/pubmed/30699343

298-64601 Human βAmyloid(1-40)ELISA Kit Wako Ⅱ

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Amyloid-β causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons

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2. Ohta, K., et al.: Autophagy, 3, 345(2010).

Autophagy impairment stimulates PS1 expression and γ-secretase activity https://www.ncbi.nlm.nih.gov/pubmed/20168091

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Hypercholesterolemia accelerates intraneuronal accumulation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice https://www.ncbi.nlm.nih.gov/pubmed/22273754

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Practical detection of a definitive biomarker panel for Alzheimer's disease; comparisons between matched plasma and cerebrospinal fluid https://www.ncbi.nlm.nih.gov/pubmed/24959311

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Potential Application of Extracellular Vesicles of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Alzheimer’s Disease Therapeutics https://www.ncbi.nlm.nih.gov/pubmed/25085563

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The effect of cognitive-motor dual-task training on cognitive function and plasma amyloid β peptide 42/40 ratio in healthy elderly persons: a randomized controlled trial https://www.ncbi.nlm.nih.gov/pubmed/26018225

7. Schütt, T., et al.: J. Vet. Intern. Med., 29, 6, 1569(2015).

Cognitive function, progression of age‐related behavioral changes, biomarkers, and survival in dogs more than 8 years old

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Dogs with Cognitive Dysfunction as a Spontaneous Model for Early Alzheimer's Disease: A Translational Study of Neuropathological and Inflammatory Markers. https://www.ncbi.nlm.nih.gov/pubmed/27003213

9. Wan, W., et al.: Exp. Gerontol., 81, 92(2016). EGb761 improves cognitive function and regulates inflammatory responses in the APP/PS1 mouse https://www.ncbi.nlm.nih.gov/pubmed/27220811
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Effect of apolipoprotein E phenotype on the association of plasma amyloid β and amyloid positron emission tomography imaging in Japan. https://www.ncbi.nlm.nih.gov/pubmed/28975146

294-62501 Human/Rat β Amyloid(40)ELISA Kit Wako

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Multifunction of myricetin on Aβ: neuroprotection via a conformational change of Aβ and reduction of Aβ via the interference of secretases

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2. Zhang, C., et al.: J. Alzheimers Dis., 22, 2, 683(2010).

Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density. https://www.ncbi.nlm.nih.gov/pubmed/20847415

3. Zhang, C., et al.: J. Biol. Chem., 285, 37, 28472(2010).

 Curcumin decreases amyloid-beta peptide levels by attenuating the maturation of amyloid-beta precursor protein.

https://www.ncbi.nlm.nih.gov/pubmed/20622013

4. Walls, K. C., et al.: J. Biol. Chem., 287, 36, 30317(2012).

Swedish Alzheimer Mutation Induces Mitochondrial Dysfunction Mediated by HSP60 Mislocalization of Amyloid Precursor Protein (APP) and Beta-Amyloid https://www.ncbi.nlm.nih.gov/pubmed/22753410

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Amyloid precursor protein (APP) contributes to pathology in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

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6. Sarajärvi, T., et al.: J. Cell Mol. Med., 16, 11, 2754(2012).

Bepridil decreases A β and calcium levels in the thalamus after middle cerebral artery occlusion in rats

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7. Vepsäläinen, S., et al.: J. Nutr. Biochem., 24, 1, 360(2013).

Anthocyanin-enriched bilberry and blackcurrant extracts modulate amyloid precursor protein processing and alleviate behavioral abnormalities in the APP/PS1 mouse model of Alzheimer's disease

https://www.ncbi.nlm.nih.gov/pubmed/22995388

8. Teich, A. F., et al.: PLoS One., 8, 2, e55647(2013).

A Reliable Way to Detect Endogenous Murine β-Amyloid https://www.ncbi.nlm.nih.gov/pubmed/23383341

9. Dolev, I., et al.: Nat. Neurosci., 16, 5, 587(2013). Spike bursts increase amyloid-β 40/42 ratio by inducing a presenilin-1 conformational change. https://www.ncbi.nlm.nih.gov/pubmed/23563578
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Specific serotonergic denervation affects tau pathology and cognition without altering senile plaques deposition in APP/PS1 mice

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11. Kitaoka, K., et al.: Neuropharmacology, 72, 58(2013).

The retinoic acid receptor agonist Am80 increases hippocampal ADAM10 in aged SAMP8 mice https://www.ncbi.nlm.nih.gov/pubmed/23624141

12. Wang, W., et al.: FASEB J., 28, 2, 849(2014).

Amyloid precursor protein α- and β-cleaved ectodomains exert opposing control of cholesterol homeostasis via SREBP2.

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13. Kanatsu, K., et al.: Nat. Commun., 5, 3386(2014).

Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase

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14. Ramos-Rodriguez, J. J., et al.: Psychoneuroendocrinology, 48, 123(2014).

Prediabetes-induced vascular alterations exacerbate central pathology in APPswe/PS1dE9 mice. https://www.ncbi.nlm.nih.gov/pubmed/24998414

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KB-R7943, an inhibitor of the reverse Na+/Ca2+ exchanger, does not modify secondary pathology in the thalamus following focal cerebral stroke in rats https://www.ncbi.nlm.nih.gov/pubmed/25123443

16. Rudnitskaya, E. A., et al.: J. Alzheimers Dis., 47, 1, 103(2015)

Melatonin attenuates memory impairment, amyloid-β accumulation, and neurodegeneration in a rat model of sporadic Alzheimer's disease

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Is L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice

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18. Kim, Y. H., et al.: Nat. Protoc., 10, 7, 985(2015).

A 3D human neural cell culture system for modeling Alzheimer's disease. https://www.ncbi.nlm.nih.gov/pubmed/26068894

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 Genetic variation in δ-opioid receptor associates with increased β-and γ-secretase activity in the late stages of Alzheimer's disease

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20. Leal, N. S., et al.: J. Cell Mol. Med., 20, 9, 1686(2016).

 Mitofusin-2 knockdown increases ER–mitochondria contact and decreases amyloid β‐ peptide production

 https://www.ncbi.nlm.nih.gov/pubmed/27203684

21. Kanatsu, K., et al.: Hum. Mol. Genet., 25, 18, 3988(2016). Partial loss of CALM function reduces Aβ42 production and amyloid deposition in vivo https://www.ncbi.nlm.nih.gov/pubmed/27466196
22. Yamaguchi, T., et al.: Sci. Rep., 6, 34505(2016).

Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing https://www.ncbi.nlm.nih.gov/pubmed/27687691

23. Sun, M., et al.: Neurobiol. Dis., 93, 1(2016).

The polarity protein Par3 regulates APP trafficking and processing through the endocytic adaptor protein Numb

https://www.ncbi.nlm.nih.gov/pubmed/27072891

24. Ramos-Rodriguez, J. J., et al.: Mol. Neurobiol., 53, 4, 2685(2016).

Increased Spontaneous Central Bleeding and Cognition Impairment in APP/PS1 Mice with Poorly Controlled Diabetes Mellitus.

https://www.ncbi.nlm.nih.gov/pubmed/26156287

25. Stefanova, N. A., et al.: Aging (Albany NY), 8, 11, 2713(2016).

An antioxidant specifically targeting mitochondria delays progression of Alzheimer's disease-like pathology.

https://www.ncbi.nlm.nih.gov/pubmed/27750209

26. Chen, W. T., et al.: PLoS One, 7, 4, e35807(2017).

Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies

https://www.ncbi.nlm.nih.gov/pubmed/22558227

27. Tateno, A., et al.: Alzheimers Dement. (Amst)., 9, 51(2017).

Effect of apolipoprotein E phenotype on the association of plasma amyloid β and amyloid positron emission tomography imaging in Japan. https://www.ncbi.nlm.nih.gov/pubmed/28975146

28. Illouz, T., et al.: J. Neurosci. Methods, 291, 28(2017).

A protocol for quantitative analysis of murine and human amyloid-β1-40 and 1-42. https://www.ncbi.nlm.nih.gov/pubmed/28768163

29. Kolosova, N. G., et al.: Curr. Alzheimer Res., 14, 12, 1283(2017).

 Antioxidant SkQ1 Alleviates Signs of Alzheimer's Disease-like Pathology in Old OXYS Rats by Reversing Mitochondrial Deterioration

https://www.ncbi.nlm.nih.gov/pubmed/28637402

30. Infante-Garcia C., et al.: Mol. Neurobiol., 54, 6, 4696(2017).

Long-Term Mangiferin Extract Treatment Improves Central Pathology and Cognitive Deficits in APP/PS1 Mice.

https://www.ncbi.nlm.nih.gov/pubmed/27443159

31. Ramos-Rodriguez, J. J., et al.: Mol. Neurobiol., 54, 5, 3428(2017).

Progressive Neuronal Pathology and Synaptic Loss Induced by Prediabetes and Type 2 Diabetes in a Mouse Model of Alzheimer's Disease.

https://www.ncbi.nlm.nih.gov/pubmed/27177549

32. Cai, T., et al.: J. Neurosci., 37, 50, 12272(2017).

Activation of γ-Secretase Trimming Activity by Topological Changes of Transmembrane Domain 1 of Presenilin 1.

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33. Kidana, K., et al.: EMBO Mol. Med., 10, 3, (2018).

Loss of kallikrein‐related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice

https://www.ncbi.nlm.nih.gov/pubmed/29311134

34. Sasaguri, H., et al.: Nat. Commun., 9, 1, 2892(2018).

Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID https://www.ncbi.nlm.nih.gov/pubmed/30042426

294-64701 Human/Rat βAmyloid(40)ELISA Kit Wako Ⅱ

1. Kawahara, K., et al.: Biol. Pharm, Bull., 32, 7, 1307(2009).

Oral administration of synthetic retinoid Am80 (Tamibarotene) decreases brain beta-amyloid peptides in APP23 mice.

https://www.ncbi.nlm.nih.gov/pubmed/19571405

2. Silverberg, G. D., et al.: Brain Res., 1317, 286(2010).

Amyloid and Tau accumulate in the brains of aged hydrocephalic rats https://www.ncbi.nlm.nih.gov/pubmed/20045398

3. Silverberg, G. D., et al.: J. Neuropathol. Exp. Neurol., 69, 1, 98(2010).

Amyloid deposition and influx transporter expression at the blood-brain barrier increase in normal aging.

https://www.ncbi.nlm.nih.gov/pubmed/20010299

4. Hashimoto, M., et al,: Acta Neuropathol., 119, 5, 543(2010).

Analysis of microdissected human neurons by a sensitive ELISA reveals a correlation between elevated intracellular concentrations of Aβ42 and Alzheimer’s disease neuropathology https://www.ncbi.nlm.nih.gov/pubmed/20198479

5. Liu, W., et al.: Neurol. Res., 34, 1, 3(2012).

Isoflurane-induced spatial memory impairment by a mechanism independent of amyloid-beta levels and tau protein phosphorylation changes in aged rats https://www.ncbi.nlm.nih.gov/pubmed/22196855

6. Kawahara, K., et al.: Neuroscience, 207, 243(2012).

Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice https://www.ncbi.nlm.nih.gov/pubmed/22342341

7. Chiu, C., et al.: Fluids Barriers CNS, 9, 1, 3(2012).

Temporal course of cerebrospinal fluid dynamics and amyloid accumulation in the aging rat brain from three to thirty months

 https://www.ncbi.nlm.nih.gov/pubmed/22269091

8. Liu, H., et al.: Neurobiol. Aging, 33, 4, 826, e31(2012)

Regulation of β-amyloid level in the brain of rats with cerebrovascular hypoperfusion. https://www.ncbi.nlm.nih.gov/pubmed/21813211

9. Keilani, S., et al.: J. Neurosci., 32, 15, 5223(2012).

Lysosomal dysfunction in a mouse model of Sandhoff disease leads to accumulation of ganglioside-bound amyloid-β peptide.

https://www.ncbi.nlm.nih.gov/pubmed/22496568

10. Beyer, A. S., et al.: Neurobiol. Aging, 33, 4, 732(2012).

Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein

 https://www.ncbi.nlm.nih.gov/pubmed/20674096

11. Ehrlich, D., et al.: Neuroscience, 205, 154(2012).

 Effects of long-term moderate ethanol and cholesterol on cognition, cholinergic neurons, inflammation, and vascular impairment in rats. https://www.ncbi.nlm.nih.gov/pubmed/22244974

12. Arnal, N., et al.: Int. J. Alzheimers Dis., 645379(2013).

Effects of Copper and/or Cholesterol Overload on Mitochondrial Function in a Rat Model of Incipient Neurodegeneration.

https://www.ncbi.nlm.nih.gov/pubmed/24363953

13. Ehrlich, D., et al.: Platelets, 24, 1, 26(2013).

Effects of oxidative stress on amyloid precursor protein processing in rat and human platelets https://www.ncbi.nlm.nih.gov/pubmed/22385218

14. Ai, J., et al.: J. Neurosci., 33, 9, 3989(2013).

MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats.

 https://www.ncbi.nlm.nih.gov/pubmed/23447608

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β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease.

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Rheb GTPase regulates β-secretase levels and amyloid β generation. https://www.ncbi.nlm.nih.gov/pubmed/24368770

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Amyloid-beta accumulation, neurogenesis, behavior, and the age of rats. https://www.ncbi.nlm.nih.gov/pubmed/24841744

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Cooperative therapeutic action of retinoic acid receptor and retinoid x receptor agonists in a mouse model of Alzheimer's disease.

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Soluble amyloid beta levels are elevated in the white matter of Alzheimer’s patients, independent of cortical plaque severity

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Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease

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Cargo Delivery into the Brain by in vivo identified Transport Peptides. https://www.ncbi.nlm.nih.gov/pubmed/26411801

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Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models https://www.ncbi.nlm.nih.gov/pubmed/26563932

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SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1

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2-Cl-MGV-1 Ameliorates Apoptosis in the Thalamus and Hippocampus and Cognitive Deficits After Cortical Infarct in Rats.

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Potent and Selective BACE-1 Peptide Inhibitors Lower Brain Aβ Levels Mediated by Brain Shuttle Transport

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 Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease. https://www.ncbi.nlm.nih.gov/pubmed/29018038

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 Aging and APOE-e4 are determinative factors of plasma Ab42 levels https://www.ncbi.nlm.nih.gov/pubmed/30349853

28. Kara, E., et al.: J. Biol. Chem., 293, 34, 13247(2018).

A flow cytometry–based in vitro assay reveals that formation of apolipoprotein E (ApoE)–amyloid beta complexes depends on ApoE isoform and cell type https://www.ncbi.nlm.nih.gov/pubmed/29950521

29. Prasad, H., et al.: Proc. Natl. Acad. Sci. USA, 115, 28, E6640(2018).

Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH.

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Endogenous Murine Amyloid-β Peptide Assembles into Aggregates in the Aged C57BL/6J Mouse Suggesting These Animals as a Model to Study Pathogenesis of Amyloid-β Plaque Formation. https://www.ncbi.nlm.nih.gov/pubmed/29376876

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Protein kinase C-activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations

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CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease.

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Oral administration of Pantoea agglomerans-derived lipopolysaccharide prevents metabolic dysfunction and Alzheimer's disease-related memory loss in senescence-accelerated prone 8 (SAMP8) mice fed a high-fat diet.

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https://www.ncbi.nlm.nih.gov/pubmed/30472734