通知

本试剂盒为“高灵敏度Mature BDNF ELISA试剂盒(产品编号:298-83901,以下称旧款试剂盒)”的改良试剂盒。旧款产品已于2023年6月30日终止销售。
相比旧款试剂盒,本产品可更高灵敏度地检测mBDNF,并且两款试剂盒的检测值具有相关性。
推荐使用过旧款试剂盒的客户继续使用本试剂盒。
脑源性神经营养因子(BDNF: Brain-derived neurotrophic factor)是大脑中丰富的神经营养因子之一,参与神经发生、神经保护和突触形成等。此外,它还有望作为抑郁症等精神疾病的生物标志物。
BDNF的前体proBDNF经加工,成为Mature BDNF(mBDNF)。据报告,proBDNF和mBDNF拥有不同的生理活性,因此,区分和检测每种BDNF非常重要。

The gold standard for autophagy research

LC3 とLC3 結合反応系 The three proteins, LC3, GABARAP (GABAA receptor-associated protein), and GATE-16 (Golgi-associated ATPase enhancer), are mammalian homologues of yeast Atg8. Among them, LC3 has been studied most extensively and frequently used as an autophagy marker in mammals. Newly translated LC3 (proLC3) is immediately processed at the C-terminus by Atg4B or Atg4A, forming LC3-I. Upon induction of autophagy, LC3-I is sequentially transferred to E1 and E2, and conjugated to the substrate, PE (phosphatidylethanolamine). The resulting PE-conjugated LC3 is called LC3-II. Although LC3-II has a higher molecular weight than LC3-I, the mobility of LC3-II is greater than LC3-I on SDS-PAGE, due to higher hydrophobicity. GABARAP and GATE-16 are also conjugated to PE in a similar process.

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